Hepatocyte CEBPA-ORM1 axis restricts alcohol-associated liver disease
These findings identify the hepatocyte CEBPA-ORM1 axis as a critical suppressor of ALD, offering therapeutic targets and nominating serum ORM1 as a potential biomarker for staging ALD severity.
Authors
- Maria A. Parra (ORCID: https://orcid.org/0009-0005-0951-2074)
- Z. J. Sun (ORCID: https://orcid.org/0000-0002-4204-9297)
- Shogo Takahashi (ORCID: https://orcid.org/0000-0002-3831-5353)
- Brandon Peiffer (ORCID: https://orcid.org/0000-0002-6783-2923)
- Kristopher W. Krausz (ORCID: https://orcid.org/0000-0003-2910-7787)
- Daisuke Aibara (ORCID: https://orcid.org/0000-0003-3437-1531)
- Frank J. Gonzalez (ORCID: https://orcid.org/0000-0002-7990-2140)
- Ravikanth Nanduri (ORCID: https://orcid.org/0000-0002-0031-2333)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-3183-0034)
- Haiping Hao
- Tingting Yan
- Vorthon Sawaswong
- Yangliu Xia
- Mengge Dai
- Xi Xu
- Yoshifumi Saito
- Nana Yan
Institutions
- Johns Hopkins University (US)
- China Pharmaceutical University (CN)
- Johns Hopkins Medicine (US)
- National Cancer Institute (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
Publication Details
- Journal
- Hepatology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1097/hep.0000000000001737
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00