ARPC1B promotes gastric cancer tumorigenesis via IGF2BP3-mediated stabilization of HK2 mRNA and glycolytic reprogramming

ARPC1B drives GC progression by stabilizing HK2 mRNA through IGF2BP3 binding, thereby potentiating glycolytic reprogramming to facilitate tumor growth and metastasis. Targeting the ARPC1B-IGF2BP3-HK2 axis may represent a novel therapeutic strategy for GC.

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Publication Details

Journal
European journal of medical research
Published
2026-03-09
DOI
https://doi.org/10.1186/s40001-026-04087-4
Primary Topic
Growth Hormone and Insulin-like Growth Factors
Type
article
Field-Weighted Citation Impact
0.00
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article

ARPC1B promotes gastric cancer tumorigenesis via IGF2BP3-mediated stabilization of HK2 mRNA and glycolytic reprogramming

Junjie Ma, Ting. Liu, Longyue Wang, Rong Yang et al.
European journal of medical research
Growth Hormone and Insulin-like Growth Factors
article

ARPC1B promotes gastric cancer tumorigenesis via IGF2BP3-mediated stabilization of HK2 mRNA and glycolytic reprogramming

Junjie Ma, Ting. Liu, Longyue Wang, Rong Yang, Yongjing Chen
article en

Abstract

ARPC1B drives GC progression by stabilizing HK2 mRNA through IGF2BP3 binding, thereby potentiating glycolytic reprogramming to facilitate tumor growth and metastasis. Targeting the ARPC1B-IGF2BP3-HK2 axis may represent a novel therapeutic strategy for GC.

European journal of medical research
Shanxi Provincial Cancer Hospital (CN)
Good health and well-being
Openalex Percentile: Top 31%
Growth Hormone and Insulin-like Growth Factors
DOIOpen Access PDFOpenAlex
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ARPC1B promotes gastric cancer tumorigenesis via IGF2BP3-mediated stabilization of HK2 mRNA and glycolytic reprogramming — Junjie Ma, Ting. Liu, et al. · European journal of medical research (2026) | TGRS Research Map | TGRS