High-pressure-driven cycloadditions: dearomatization of electron-deficient arenes

Dearomative cycloadditions transform planar structures into intricate three-dimensional polycyclic compounds. The scope of these reactions is limited however due to steric or electronic limitations. High-pressure conditions provide an effective way to overcome these challenges, often minimizing the formation of side products and eliminating the need for chemical catalysts. This article showcases recent advances from our group, revealing that high-pressure-induced cycloadditions facilitate the efficient transformation of electron-deficient arenes into complex molecules under conditions that promote sustainable chemistry.