Divergent CD27 expression marks the Treg induction trajectory
Our results define a population of induced Tregs <i>in vitro</i> and <i>in vivo</i> that is marked by elevated CD27 expression. Hence, CD27 expression may be useful to monitor therapeutic efficacy of Treg induction <i>in vivo</i> in clinical trials.
Authors
- Jaap Jan Zwaginga (ORCID: https://orcid.org/0000-0003-1228-7769)
- Antoinette M. Joosten
- Diahann T. S. L. Jansen (ORCID: https://orcid.org/0000-0003-4535-9167)
- Bart O. Roep (ORCID: https://orcid.org/0000-0002-3110-7391)
- Chelsea Gootjes (ORCID: https://orcid.org/0000-0002-6811-2290)
- Tatjana Nikolić (ORCID: https://orcid.org/0000-0002-5651-8269)
- Maurits G. Staal
Institutions
- Immune Regulation (United Kingdom) (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fimmu.2026.1756275
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00