Study of young psychiatric patients shows potential preventive benefit of doxycycline

A study using an emulated target trial design has found a reduced long‐term risk of a diagnosis of schizophrenia in adolescents who had received psychiatric treatment and had incidentally also received treatment with the broad‐spectrum tetracycline antibiotic doxycycline. Risk of schizophrenia at 10 years was significantly lower in individuals who had taken doxycycline compared with those receiving other antibiotics.

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2026-02-23
DOI
https://doi.org/10.1002/pu.31418
Primary Topic
Schizophrenia research and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Study of young psychiatric patients shows potential preventive benefit of doxycycline

The Brown University Psychopharmacology Update
Schizophrenia research and treatment
article

Study of young psychiatric patients shows potential preventive benefit of doxycycline

article en

Abstract

A study using an emulated target trial design has found a reduced long‐term risk of a diagnosis of schizophrenia in adolescents who had received psychiatric treatment and had incidentally also received treatment with the broad‐spectrum tetracycline antibiotic doxycycline. Risk of schizophrenia at 10 years was significantly lower in individuals who had taken doxycycline compared with those receiving other antibiotics.

The Brown University Psychopharmacology UpdateVol. 37(3)
Good health and well-being
Openalex Percentile: Top 37%
Schizophrenia research and treatment
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