Dual tumor microenvironment-responsive albumin nanoplatform integrates conditional PROTAC activation with starvation and ferroptosis for synergistic cancer therapy
This study demonstrates a precision therapeutic paradigm. It exploits tumor microenvironment characteristics to couple conditional drug activation with starvation and ferroptosis. This strategy offers a translatable framework for next generation's cancer treatment.
Authors
- J. L. Liu
- Lingting Lin
- Wenfei Niu
- Wei Xu (ORCID: https://orcid.org/0000-0001-8006-2399)
- Yan Yang (ORCID: https://orcid.org/0000-0001-8146-8040)
- Hua Li
- Binyu Chen
- Ruocheng Deng
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1186/s12951-026-04266-9
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00