Effects of Glycine on Mismatch Negativity and the Underlying Theta-Band Signature in the Ketamine Model of Schizophrenia in Healthy Men
This is the first study in humans to investigate the effects of glycine on the MMN in the ketamine model of schizophrenia. The results confirm a key role of the glutamate system for pre-attentive auditory processing deficits underlying the symptoms of schizophrenia. From a translational perspective, the MMN and its theta-band signature may serve as biomarkers to identify patients who may benefit from glutamatergic treatment options.
Authors
- Christoph Mulert (ORCID: https://orcid.org/0000-0001-8214-5868)
- Tarik Korkutan
- Gregor Leicht (ORCID: https://orcid.org/0000-0002-5104-9336)
- Stjepan Ćurić
- Moritz Haaf (ORCID: https://orcid.org/0000-0002-9601-1497)
- S. Rusche
- Darius Zokai
- Jonas Rauh
Institutions
- Harvard University (US)
- Universität Hamburg (DE)
- Justus-Liebig-Universität Gießen (DE)
- Massachusetts General Hospital (US)
- University Medical Center Hamburg-Eppendorf (DE)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1093/schbul/sbaf227
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00