Tumor Treating Fields (TTFields), and their concomitant application with FOLFOX, are effective for the treatment of gastric cancer cells
The study shows that TTFields induce an antimitotic effect and impair DNA damage repair in gastric cancer cells, and that concomitant treatment with FOLFOX improves treatment efficacy <i>in vitro</i>, potentially due to the accumulation of DNA damage. Overall, TTFields treatment holds potential for treatment of gastric cancer alongside standard chemotherapy.
Authors
- Naama Flint-Brodsly
- Tali Voloshin (ORCID: https://orcid.org/0000-0002-5463-3941)
- Hila Fishman
- Antonia Martinez-Conde
- Einav Zeevi
- Eyal Dor-On (ORCID: https://orcid.org/0000-0003-3166-6764)
- Adi Haber (ORCID: https://orcid.org/0000-0002-6025-4980)
- Shiri Davidi
- Gitit Lavy-Shahaf
- Roni Frechtel-Gerzi
- Moshe Giladi (ORCID: https://orcid.org/0000-0003-1489-4175)
- Yoram Palti (ORCID: https://orcid.org/0000-0003-4076-2184)
- Hila M Ene
- Kerem Wainer-Katsir
- Shany Greenstein
- Yaara Porat
- Uri Weinberg
- Mijal Munster
Institutions
- Novocure (United States) (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fonc.2026.1575083
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00