Divergent Immunological and Neurotrophic Responses to CD20 Depletion in Relapsing and Progressive Multiple Sclerosis
Our findings support divergent immunological mechanisms in RMS and PPMS, with a stronger cytokine-driven pathology and more pronounced immunomodulatory effects of ocrelizumab on the cytokine profile in patients with RMS.
Authors
- Julian Reza Kretschmer
- Gudrun Körner (ORCID: https://orcid.org/0000-0003-1919-0070)
- Philipp Schwenkenbecher (ORCID: https://orcid.org/0000-0002-1260-1650)
- Jarle von Hörsten
- Janna Margaretha Siemer
- Franz Felix Konen (ORCID: https://orcid.org/0000-0002-8609-5674)
- Franziska Bachhuber (ORCID: https://orcid.org/0000-0003-1031-9966)
- Thiemo Malte Möllenkamp
- Anna Christina Saparilla Pietschmann
- Martin W. Hümmert
- Konstantin F. Jendretzky
- Roland Jacobs
- Thomas Skripuletz
- Hayrettin Tumani
- Stefan Gingele
Institutions
- Medizinische Hochschule Hannover (DE)
- University Hospital of Zurich (CH)
- University Hospital Münster (DE)
- KRH Klinikum Agnes Karll Laatzen (DE)
- University Hospital Ulm (DE)
Publication Details
- Journal
- Neurology and Therapy
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1007/s40120-026-00908-0
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00