Syntaxin 4 protects islet β-cells from cytokine-induced senescence
These findings indicate that STX4 protects β-cells from cytokine or bleomycin-induced senescence and suggest that enhancing STX4 activity may be a therapeutic strategy to preserve functional β-cell mass in T1D.
Authors
- Debbie C. Thurmond (ORCID: https://orcid.org/0000-0002-6303-4596)
- Erika M. McCown
- Sneha S. Varghese (ORCID: https://orcid.org/0000-0001-5526-5856)
- Katarzyna Dąbrowska (ORCID: https://orcid.org/0000-0001-7833-0374)
- Patrick Pirrotte (ORCID: https://orcid.org/0000-0003-1360-6039)
- Sangeeta Dhawan (ORCID: https://orcid.org/0000-0002-1562-7899)
- Brooke Lovell (ORCID: https://orcid.org/0009-0008-1023-2186)
- S. Bhattacharya (ORCID: https://orcid.org/0000-0003-0483-2149)
- Miwon Ahn (ORCID: https://orcid.org/0009-0000-5723-4447)
- Eunjin Oh
- Nathaniel Hansen
Institutions
- Translational Genomics Research Institute (US)
- City Of Hope National Medical Center (US)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fendo.2026.1725252
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00