Tissue Damage in Rheumatoid Arthritis is Genetically linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts
Genetically determined low PAM reduces the anti-inflammatory and tissue damaging activities of ADM and PAMP mediated by macrophages and RASFs explaining the association of rs26232 C with RA severity.
Authors
- Richard E. Mains (ORCID: https://orcid.org/0000-0003-1154-1331)
- Betty Eipper (ORCID: https://orcid.org/0000-0003-1171-5557)
- Munitta Muthana (ORCID: https://orcid.org/0000-0003-2497-8903)
- M. Fisher
- C. P. Buckley
- Sam Pledger
- Emma Dorris
- Kevin J. Sheridan
- Jemma Falkov
- Hector Devey
- Maria Inês Pimenta
- Denis C. Shields
- Anthony G. Wilson
Institutions
- University College Dublin (IE)
- University of Oxford (GB)
- UConn Health (US)
- University of Sheffield (GB)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1002/art.70123
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00