Lactylation‐Driven Macrophage Polarisation Regulates Pulp Inflammation
This study revealed that elevated lactate production in the inflammatory microenvironment roles as a mediator of immunometabolic crosstalk, bridging dental pulp cells-macrophage communication. And the mechanism involved in lactylation induced metabolic reprogramming. This helps to better understand the repair potential of inflamed dental pulp, supporting biologically-based preservation approaches.
Authors
- L. L. Chen
- Wei Yi (ORCID: https://orcid.org/0000-0002-4349-910X)
- Zheng Wang (ORCID: https://orcid.org/0000-0003-4873-505X)
- Wanli Xu (ORCID: https://orcid.org/0009-0006-8484-0438)
- Hang Zhao (ORCID: https://orcid.org/0000-0002-1069-569X)
- Xiaolin Lyu
- Wenan Xu
- Buling Wu
- Tingyun Xu
Institutions
- Stomatology Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1111/iej.70136
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00