Behavioral, antioxidant, and kynurenine pathway modulation of a specific strain of Ligilactobacillus salivarius in a preclinical model of depression
Ligilactobacillus salivarius CECT 30632 improved behavioral outcomes, enhanced antioxidant defenses, and modulated tryptophan metabolism in a rat model of CMS. These findings support its potential as a probiotic intervention for depression.
Authors
- Javier R. Caso (ORCID: https://orcid.org/0000-0001-8622-749X)
- Jose Miguel Rizo
- César Díaz-García (ORCID: https://orcid.org/0009-0006-2019-8570)
- David Martín-Hernández
- Pedro-Antonio Regidor
- Juan Carlos Leza
- Marta Román
- Rocío Gutiérrez
Institutions
- Instituto Cajal (ES)
- Instituto de Salud Carlos III (ES)
- Research Institute Hospital 12 de Octubre (ES)
- IMDEA Software Institute (ES)
- Medical Research Network (US)
Publication Details
- Journal
- European Journal of Nutrition
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1007/s00394-026-03941-9
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00