Multiple-element exposure in early pregnancy and birth defects: a nested case–control study based on the China birth cohort study
The mixture of high levels of Al, Cr, Mn, Fe, Ni, and Zn in urine during the first trimester of pregnancy was related to a reduction in total birth defects. In particular, the influence of Ni and Zn on total birth defects should be considered.
Authors
- Yi Yang (ORCID: https://orcid.org/0000-0002-4091-8532)
- Weichunbai Zhang
- Yunjia Yang (ORCID: https://orcid.org/0000-0002-0538-6235)
- Ying Li (ORCID: https://orcid.org/0000-0002-0882-5926)
- Qin Mao (ORCID: https://orcid.org/0009-0008-6146-7794)
- Jing Du (ORCID: https://orcid.org/0000-0001-9005-9046)
- Yao Sun (ORCID: https://orcid.org/0000-0002-7268-9201)
- Jilong Yao
- Jianming Zhang
- Yan Song
- Tianhao Shan
- Hong Li
Institutions
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- China National Center for Food Safety Risk Assessment (CN)
- Beijing Center for Disease Prevention and Control (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fnut.2026.1722672
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China National Center for Food Safety Risk Assessment
- National Key Research and Development Program of China