Dynamics of matrix metalloproteinases and procollagen type-1 <i>N</i> -terminal propeptide following right ventricular outflow tract reconstruction: the protective mechanism of restrictive physiology
Persistent elevation of matrix metalloproteinase-2 and procollagen type-1 <i>N</i>-terminal propeptide reflects an active "remodeling" process. Restrictive physiology is associated with the "Biological Banding" mechanism. By increasing myocardial stiffness, this adaptive process is linked to protecting the right ventricle from irreversible dilation under chronic volume overload.
Authors
- Onur Benli (ORCID: https://orcid.org/0000-0003-3623-6130)
- Mehmet Şah Topçuoğlu (ORCID: https://orcid.org/0000-0001-6848-2577)
- Orhan Kemal Sali̇h (ORCID: https://orcid.org/0000-0001-5582-5331)
- Atakan Atalay (ORCID: https://orcid.org/0000-0002-7700-5964)
- Hafize YALINIZ
- Mehmet Aslan
- Murat Yüksel
- Ugur Gocen
- Hakan Poyrazoglu
- Sevcan Erdem
Institutions
- Memorial Ankara Hospital (TR)
- City Hospital (GB)
- Hospital Garcia de Orta (PT)
- Department of Public Health (MM)
- Lifeline Hospital (IN)
- Cukurova University (TR)
Publication Details
- Journal
- Cardiology in the Young
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1017/s1047951126111615
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00