Lab-on-a-Chip Analysis Using Benchtop NMR Technology
We present the design and optimization of a benchtop NMR spectrometer for real-time metabolic monitoring of 3D tissue on microfluidic platforms, utilizing hyperpolarization via dynamic nuclear polarisation. We show the modifications made to a commercial benchtop NMR spectrometer, the design and fabrication of a microfluidic platform ensuring consistent injection of hyperpolarized substrates and ongoing cell media renewal, and its integration with a radio frequency (RF) coil for data transmission and reception (Tx/Rx). Additionally, the construction of a sample carrier is presented. Preliminary NMR results from this system are also provided.
Authors
- Dubois J-M M
- Marco Rius I.
- Fallon M.
- Ramón Azcón J.
- Benamara Megdouda
- Yeste J.
- Weerakonda D.
- Herrero A.
- Patel H.
- Azagra M.
- Portela A.
- Antonakakis T.
Publication Details
- Published
- 2026-03-09
- DOI
- https://doi.org/10.31428/10317/13704
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Agencia Estatal de Investigación
- European Social Fund