Preclinical advances and mechanistic insights of CAR-T therapy for acute myeloid leukemia: from target iteration to microenvironment regulation
Multidimensional technological innovation and the synergistic optimization of combination therapies are critical to overcoming AML-specific barriers. These advances hold the potential to unlock the precise clinical application of CAR-T therapy, ultimately improving survival outcomes for patients with relapsed/refractory AML.
Authors
- Chao Cui (ORCID: https://orcid.org/0000-0002-7868-6263)
- Jingfei Shi (ORCID: https://orcid.org/0000-0002-7879-9671)
- Lu Liu (ORCID: https://orcid.org/0000-0002-7496-5564)
- Shumei Liu
- Ziyi Shao
- Jinfeng Tian
- Lijing Wang
- Yang Xiao
Institutions
- Shandong Xiehe University (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1080/07853890.2026.2640457
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province