Fibrosis‐Driven Surgical Risk After Thyroid Nodule Ablation: Quantitative Clinicopathological Determinants of Complications in Post‐Ablative Thyroidectomy—A Retrospective Cohort Study
Thyroidectomy after prior ablation is feasible in experienced centers but may be technically demanding and associated with modestly increased procedural complexity. Mature sclerosis represents the principal histological correlate of perioperative morbidity, linking fibrotic remodeling to operative risk. These findings support centralization of postablation thyroid surgery in high-volume units with routine neuromonitoring and specialized pathology and highlight the need for larger prospective studies to validate fibrosis-based risk stratification tools.
Authors
- Francesco Brucchi (ORCID: https://orcid.org/0000-0003-3191-4369)
- Carla Maria Colombo (ORCID: https://orcid.org/0000-0003-0716-481X)
- Laura Fugazzola (ORCID: https://orcid.org/0000-0001-5372-0982)
- D Zhang
- Giacomo Gazzano
- Andrea Satta
- Gianlorenzo Dionigi
- Alvino Boero
Institutions
- AOL (United States) (US)
- University of Milan (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Union Hospital (CN)
Publication Details
- Journal
- World Journal of Surgery
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1002/wjs.70300
- Primary Topic
- Thyroid and Parathyroid Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00