Fibrosis‐Driven Surgical Risk After Thyroid Nodule Ablation: Quantitative Clinicopathological Determinants of Complications in Post‐Ablative Thyroidectomy—A Retrospective Cohort Study

Thyroidectomy after prior ablation is feasible in experienced centers but may be technically demanding and associated with modestly increased procedural complexity. Mature sclerosis represents the principal histological correlate of perioperative morbidity, linking fibrotic remodeling to operative risk. These findings support centralization of postablation thyroid surgery in high-volume units with routine neuromonitoring and specialized pathology and highlight the need for larger prospective studies to validate fibrosis-based risk stratification tools.

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Publication Details

Journal
World Journal of Surgery
Published
2026-03-08
DOI
https://doi.org/10.1002/wjs.70300
Primary Topic
Thyroid and Parathyroid Surgery
Type
article
Field-Weighted Citation Impact
0.00
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article

Fibrosis‐Driven Surgical Risk After Thyroid Nodule Ablation: Quantitative Clinicopathological Determinants of Complications in Post‐Ablative Thyroidectomy—A Retrospective Cohort Study

Francesco Brucchi, Carla Maria Colombo, Laura Fugazzola, D Zhang et al.
World Journal of Surgery
Thyroid and Parathyroid Surgery
article

Fibrosis‐Driven Surgical Risk After Thyroid Nodule Ablation: Quantitative Clinicopathological Determinants of Complications in Post‐Ablative Thyroidectomy—A Retrospective Cohort Study

Francesco Brucchi, Carla Maria Colombo, Laura Fugazzola, D Zhang, Giacomo Gazzano, Andrea Satta, Gianlorenzo Dionigi, Alvino Boero
article en

Abstract

Thyroidectomy after prior ablation is feasible in experienced centers but may be technically demanding and associated with modestly increased procedural complexity. Mature sclerosis represents the principal histological correlate of perioperative morbidity, linking fibrotic remodeling to operative risk. These findings support centralization of postablation thyroid surgery in high-volume units with routine neuromonitoring and specialized pathology and highlight the need for larger prospective studies to validate fibrosis-based risk stratification tools.

World Journal of Surgery
AOL (United States) (US), University of Milan (IT), IRCCS Istituto Auxologico Italiano (IT), Union Hospital (CN)
Good health and well-being
Openalex Percentile: Top 30%
Thyroid and Parathyroid Surgery
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Fibrosis‐Driven Surgical Risk After Thyroid Nodule Ablation: Quantitative Clinicopathological Determinants of Complications in Post‐Ablative Thyroidectomy—A Retrospective Cohort Study — Francesco Brucchi, Carla Maria Colombo, et al. · World Journal of Surgery (2026) | TGRS Research Map | TGRS