<scp> <i>Staphylococcus aureus</i> </scp> Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma
SE-producing S. aureus promotes skin barrier impairment in CTCL through cytokine-driven, JAK-dependent repression of structural proteins in keratinocytes. These findings identify microbial-immune crosstalk as a contributor to CTCL skin pathology and provide mechanistic rationale for strategies targeting S. aureus colonisation as adjunctive therapy in CTCL.
Authors
- Saptaswa Dey (ORCID: https://orcid.org/0000-0001-7532-7858)
- L. Iversen
- Lise M. Lindahl (ORCID: https://orcid.org/0000-0003-3768-4146)
- Carsten Geisler (ORCID: https://orcid.org/0000-0002-8472-0771)
- Michael Bzorek (ORCID: https://orcid.org/0000-0002-9493-5856)
- Ziao Zeng (ORCID: https://orcid.org/0000-0002-9138-602X)
- Lise Mette Rahbek Gjerdrum (ORCID: https://orcid.org/0000-0003-4377-3209)
- Anders Woetmann (ORCID: https://orcid.org/0000-0002-3008-735X)
- Chella Krishna Vadivel (ORCID: https://orcid.org/0000-0002-3710-5143)
- Terkild B. Buus (ORCID: https://orcid.org/0000-0001-7180-6384)
- Emil M.H. Pallesen (ORCID: https://orcid.org/0000-0002-3712-0781)
- Sana Ahmad (ORCID: https://orcid.org/0000-0003-3309-8350)
- Pia Rantakari (ORCID: https://orcid.org/0000-0003-1638-5075)
- Riitta Lahesmaa
- Charlotte Menné Bonefeld
- Thomas Litman
- Lang Yan
- Maria R. Kamstrup
- Sisse Rye Ostrowski
- Peter Wolf
- Martin R. J. Namini
- Maria Gluud
- Niels Ødum
- Erik Sørensen
Institutions
- University of Copenhagen (DK)
- Åbo Akademi University (FI)
- University of Turku (FI)
- Turku Centre for Computer Science (FI)
- Medical University of Graz (AT)
- Frederiksberg Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Zealand University Hospital (DK)
- BioTechMed-Graz (AT)
- LEO Foundation (DK)
- Turku Centre for Biotechnology (FI)
Publication Details
- Journal
- Allergy
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1111/all.70292
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00