Pregnancy Outcomes in Isolated Fetal Cerebral Ventriculomegaly

Abstract Fetal cerebral ventriculomegaly (VM) is a commonly observed anomaly on prenatal ultrasound, and its prognosis varies depending on the severity and associated anomalies. It may be an isolated and sole finding in some patients. The neurodevelopmental outcomes of patients diagnosed with isolated VM are controversial, and different results are available. The aim of the study was to evaluate the neurodevelopmental outcomes of isolated fetal cerebral VM. A retrospective analysis of 99 cases of isolated VM diagnosed between January 2021 and October 2023 at a tertiary center was performed. Cases were categorized based on VM severity, gestational age at diagnosis, and laterality. Neurodevelopmental outcomes were assessed via structured interviews and medical records. Normal neurodevelopmental outcomes were found in 95.4% of mild, 66.6% of moderate, and 20% of severe VM cases. Bilateral VM was significantly associated with abnormal outcomes. Early diagnosis (< 24 weeks) was more likely in severe cases. Even isolated mild VM may be associated with adverse neurodevelopmental outcomes. Detailed postnatal follow-up is recommended, especially for early-diagnosed and bilateral cases.