Reporting practices and impact of withdrawal of life-sustaining treatment on outcomes in acute brain injury clinical trials: a literature review and simulation study

WLST is poorly reported in contemporary ABI trials. Misclassification of WLST-related deaths leads to important bias in trial-reported treatment effects, potentially yielding underpowered studies and erroneous trial conclusions. Standardized, transparent WLST reporting is essential to strengthen ABI trial design and interpretation.

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Publication Details

Journal
Critical Care
Published
2026-03-08
DOI
https://doi.org/10.1186/s13054-026-05929-7
Primary Topic
Traumatic Brain Injury and Neurovascular Disturbances
Type
article
Field-Weighted Citation Impact
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article

Reporting practices and impact of withdrawal of life-sustaining treatment on outcomes in acute brain injury clinical trials: a literature review and simulation study

Christopher J. Yarnell, Kuan Liu, Shaurya Taran, Victoria A. McCredie et al.
Critical Care
Traumatic Brain Injury and Neurovascular Disturbances
article

Reporting practices and impact of withdrawal of life-sustaining treatment on outcomes in acute brain injury clinical trials: a literature review and simulation study

Christopher J. Yarnell, Kuan Liu, Shaurya Taran, Victoria A. McCredie, Jeffrey M Singh, Neill K. J. Adhikari, Damon C. Scales
article en

Abstract

WLST is poorly reported in contemporary ABI trials. Misclassification of WLST-related deaths leads to important bias in trial-reported treatment effects, potentially yielding underpowered studies and erroneous trial conclusions. Standardized, transparent WLST reporting is essential to strengthen ABI trial design and interpretation.

Critical Care
Sunnybrook Health Science Centre (CA), University Health Network (CA), University of Toronto (CA), Toronto Western Hospital (CA), Scarborough Health Network (CA), Toronto Rehabilitation Institute (CA), Toronto General Hospital (CA), Health Sciences Centre (CA), Toronto General Hospital Research Institute
Openalex Percentile: Top 36%
Traumatic Brain Injury and Neurovascular Disturbances
DOIOpen Access PDFOpenAlex
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Reporting practices and impact of withdrawal of life-sustaining treatment on outcomes in acute brain injury clinical trials: a literature review and simulation study — Christopher J. Yarnell, Kuan Liu, et al. · Critical Care (2026) | TGRS Research Map | TGRS