Enhancing Endogenous Hyaluronic Acid in Osteoarthritic Joints with an Anti‐Inflammatory Supramolecular Nanofiber Hydrogel Delivering HAS2 Lentivirus (Small 40/2024)
Osteoarthritis In article number 2400542, Feng Zhou, Qian Chen, Bin Li, and co-workers present a hyaluronan synthase 2-encoding lentivirus-loaded dexamethasone sodium phosphate hydrogel (HAS2@DexP-Gel). The hydrogel enhances endogenous hyaluronan production, reduces synovial inflammation, and delays cartilage degeneration. This research introduces a novel combinatorial nanotherapy approach for treating osteoarthritis.
Authors
- Muchao Chen (ORCID: https://orcid.org/0000-0002-2703-5516)
- Yufan Qian
- Xuequan Han (ORCID: https://orcid.org/0000-0001-5629-5918)
- Weishan Wang
- Qian Chen
- Kai Yuan
- Bin Li
- Jiong Jiong Guo
- Feng Zhou
Institutions
- Shihezi University (CN)
- Shandong University (CN)
- Shanghai Jiao Tong University (CN)
- Soochow University (CN)
- Shanghai Ninth People's Hospital (CN)
- First Affiliated Hospital of Shihezi University Medical College (CN)
- First Affiliated Hospital of Soochow University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Small
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/smll.202470300
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94