Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes
We developed a trans-ancestry PRS that outperformed the European-based GRS2x. Importantly, TA-PS provides a comparable prediction in various ancestries, which supports its use in population-wide screening programmes.
Authors
- Isabel Gamache (ORCID: https://orcid.org/0000-0002-0613-0979)
- Lauric Ferrat (ORCID: https://orcid.org/0000-0002-3166-9685)
- Basile Jumentier
- Wei Wu (ORCID: https://orcid.org/0000-0002-6556-067X)
- Tianyuan Lu
- Hui-Qi Qu
- Hakon Hakonarson
- Celia M. T. Greenwood
- Wiame Belbellaj
- Yangxi Li
- Kathleen Klein
- Kai Liu
Institutions
- University of Geneva (CH)
- Children's Hospital of Philadelphia (US)
- University of Wisconsin–Madison (US)
- University of Iceland (IS)
- McGill University Health Centre (CA)
- Jewish General Hospital (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Children's Hospital of Zhejiang University (CN)
- McGill University (CA)
- Université de Montréal (CA)
- University of Pennsylvania (US)
Publication Details
- Journal
- Diabetologia
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1007/s00125-026-06706-5
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children's Hospital of Philadelphia
- International Society for Pediatric and Adolescent Diabetes
- National Institutes of Health
- Fonds de Recherche du Québec - Santé