Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk
Retroelements contribute to the structural and expression evolution of PSG genes, facilitating lineage-specific placental evolution. The LTR8B/PSG9 regulatory network plays a central role in syncytiotrophoblast differentiation. Given the association between DLX5/GATA3 dysregulation and elevated PSG9 levels, along with PSG9's expression in the first trimester, PSG9 shows potential as a predictive biomarker for preeclampsia.
Authors
- Julianna Zadora
- Gabriela Dveksler (ORCID: https://orcid.org/0000-0003-3037-1155)
- Sandra M. Blois (ORCID: https://orcid.org/0000-0002-0434-2660)
- Laurence D. Hurst (ORCID: https://orcid.org/0000-0002-1002-1054)
- Zsuzsanna Izsvák (ORCID: https://orcid.org/0000-0002-2053-2384)
- Yuliang Qu (ORCID: https://orcid.org/0000-0002-6203-0032)
- Attila Molvarec (ORCID: https://orcid.org/0000-0002-3229-3034)
- Mark Cohen (ORCID: https://orcid.org/0000-0001-9288-9270)
- Cédric Feschotte (ORCID: https://orcid.org/0000-0002-8772-6976)
- Ralf Dechend (ORCID: https://orcid.org/0000-0001-6636-3080)
- Amit Pande (ORCID: https://orcid.org/0000-0001-5379-4746)
- Rabia Anwar
- Manvendra Singh
- Bin Zhang
- Jichang Wang
- Florian Herse
- Martin Gauster
- Katarina Stevanovic
- Xuhui Kong
- Miriam K. Konkel
- Rongyan Zheng
Institutions
- Semmelweis University (HU)
- University of Geneva (CH)
- Uniformed Services University of the Health Sciences (US)
- Inserm (FR)
- Sun Yat-sen University (CN)
- Universität Hamburg (DE)
- Medical University of Graz (AT)
- Université Paris Cité (FR)
- Max Delbrück Center (DE)
- Humboldt-Universität zu Berlin (DE)
- Institut Necker Enfants Malades (FR)
- University Medical Center Hamburg-Eppendorf (DE)
- Mohamed bin Zayed University of Artificial Intelligence (AE)
- German Centre for Cardiovascular Research (DE)
- Helios Hospital Berlin-Buch (DE)
- Institut des Maladies Génétiques Imagine (FR)
- University of Bath (GB)
- Clemson University (US)
Publication Details
- Journal
- Genome biology
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1186/s13059-026-03944-z
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00