A Silent Saboteur of Immunotherapy: Antibiotic Use and Its Impact on Immune Checkpoint Inhibitors Efficacy, a Systematic Review and Meta-Analysis of Recent Studies
ABT administered in temporal proximity to ICIs is associated with clinically meaningful worsening of survival outcomes across solid tumors, consistent with microbiome-mediated impairment of immunotherapy efficacy. These findings support cautious ABT stewardship in patients receiving ICIs and highlight the need for prospective studies integrating microbiome profiling and standardized ABT exposure assessment.
Authors
- Francesca Wanda Basile
- Oreste Claudio Buonomo (ORCID: https://orcid.org/0000-0002-9531-8737)
- Giuliana Ciappina (ORCID: https://orcid.org/0000-0003-0813-3126)
- Antonio Bottari (ORCID: https://orcid.org/0000-0002-7425-7832)
- Tindara Franchina (ORCID: https://orcid.org/0000-0001-5920-4997)
- Enrica Toscano (ORCID: https://orcid.org/0009-0003-2362-764X)
- Mariapia Marafioti (ORCID: https://orcid.org/0009-0007-8807-6163)
- Guglielmo Nasti
- Gianluca Vanni
- Vincenzo Quagliariello
- Nicola Maurea
- Massimiliano Berretta
- Giordana Di Mauro
Institutions
- University of Messina (IT)
- University of Ferrara (IT)
- Ospedale Santa Maria (IT)
- Policlinico Tor Vergata (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
Publication Details
- Journal
- Cancers
- Published
- 2026-03-08
- DOI
- https://doi.org/10.3390/cancers18050869
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00