From channel‐spatial attention to state space models: A review of evolving mechanisms in tumour segmentation

Abstract Objective This review delineates the evolution of attention architectures in automated tumor segmentation across three pivotal paradigms: classic Pre‐Transformer attention, dominant Transformer‐based self‐attention, and emerging Mamba‐based state space models. Methods We synthesize their functional roles—from channel enhancement to long‐range dependency modelingand critically assess hybrid structures designed for multimodal clinical oncology scenarios. Findings/Results The review establishes attention mechanisms as a foundational pillar for the next generation of intelligent segmentation tools, highlighting their potential in feature enhancement and localization. Conclusion Interrogating current challenges and charting future trajectories, these mechanisms are poised to profoundly impact the landscape of precision medicine.

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Publication Details

Journal
Clinical and Translational Discovery
Published
2026-02-26
DOI
https://doi.org/10.1002/ctd2.70127
Primary Topic
Advanced Neural Network Applications
Type
article
Field-Weighted Citation Impact
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article

From channel‐spatial attention to state space models: A review of evolving mechanisms in tumour segmentation

Rui Yin, Yi-Xiang Wang, Yanfei Sun
Clinical and Translational Discovery
Advanced Neural Network Applications
article

From channel‐spatial attention to state space models: A review of evolving mechanisms in tumour segmentation

Rui Yin, Yi-Xiang Wang, Yanfei Sun
article en

Abstract

Abstract Objective This review delineates the evolution of attention architectures in automated tumor segmentation across three pivotal paradigms: classic Pre‐Transformer attention, dominant Transformer‐based self‐attention, and emerging Mamba‐based state space models. Methods We synthesize their functional roles—from channel enhancement to long‐range dependency modelingand critically assess hybrid structures designed for multimodal clinical oncology scenarios. Findings/Results The review establishes attention mechanisms as a foundational pillar for the next generation of intelligent segmentation tools, highlighting their potential in feature enhancement and localization. Conclusion Interrogating current challenges and charting future trajectories, these mechanisms are poised to profoundly impact the landscape of precision medicine.

Clinical and Translational DiscoveryVol. 6(2)
Shanghai Innovative Research Center of Traditional Chinese Medicine (CN), Shanghai Fudan Microelectronics (China) (CN)
Openalex Percentile: Top 31%
Advanced Neural Network Applications
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