Simulation‐Informed Evaluation of Microvascular Parameter Mapping for Diffusion MR Imaging of Solid Tumours
Simulation-based modelling of the vascular dMRI signal suggests <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:semantics> <mml:mrow> <mml:msub><mml:mrow><mml:mi>q</mml:mi></mml:mrow> <mml:mrow><mml:mi>m</mml:mi></mml:mrow> </mml:msub> </mml:mrow> <mml:annotation>$$ {q}_m $$</mml:annotation></mml:semantics> </mml:math> and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:semantics><mml:mrow><mml:mi>A</mml:mi> <mml:mi>N</mml:mi> <mml:mi>B</mml:mi></mml:mrow> <mml:annotation>$$ ANB $$</mml:annotation></mml:semantics> </mml:math> as the most promising metrics for tissue microvasculature characterisation. Their estimation in vivo appears feasible to capture general trends, and demonstrates contrasts that are biologically plausible, encouraging their usage in future studies.
Authors
- Luz M. Atlagich
- Francesco Grussu (ORCID: https://orcid.org/0000-0002-0945-3909)
- Marco Alberto Palombo
- Francesc Salvà (ORCID: https://orcid.org/0000-0001-9240-4907)
- Olivia Prior (ORCID: https://orcid.org/0009-0000-4913-6716)
- Athanasios Grigoriou (ORCID: https://orcid.org/0000-0003-1826-8040)
- Elena M Elez
- Anna Voronova (ORCID: https://orcid.org/0009-0006-9600-0436)
- Els Fieremans
- Roser Sala‐Llonch
- Dmitry S. Novikov
- Raquel Perez‐Lopez
Institutions
- Hebron University (PS)
- Vall d'Hebron Institut de Recerca (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Institute for Research in Biomedicine (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Vall d'Hebron Institute of Oncology (ES)
- New York University (US)
- Cardiff University (GB)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1002/mrm.70318
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Prostate Cancer Foundation
- Fundación BBVA
- Fundación Cellex
- UK Research and Innovation
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Banco Bilbao Vizcaya Argentaria
- Fundación Fero
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- CRIS Cancer Foundation
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación