Double Jeopardy: Multidisciplinary Approach to a Rare Case of Simultaneous Maxillary and Mandibular Mucormycosis

ABSTRACT Background Mucormycosis is a rare, life‐threatening opportunistic fungal infection that typically affects immunocompromised patients. Simultaneous involvement of both the maxilla and mandible is exceptionally rare, presenting unique diagnostic and therapeutic challenges. Case Report A 52‐year‐old female presented with bilateral maxillary and mandibular mucormycosis with a history of hospitalisation 3 months back. The patient presented with persistent pain, purulent discharge, and exposed necrotic bone in both jaws. Diagnosis was confirmed through histopathological examination revealing characteristic broad, aseptate, right‐angle branching fungal hyphae. Management involved intravenous liposomal amphotericin B (total dose 2500 mg) and aggressive surgical debridement including partial maxillectomy and removal of necrotic medullary bone from the mandible. The patient showed complete healing at 3‐month follow‐up. Conclusion This case report describes a rare presentation of simultaneous maxillary and mandibular mucormycosis and highlights the importance of maintaining high clinical suspicion. Early diagnosis and aggressive multidisciplinary treatment are crucial for optimal outcomes in this life‐threatening condition.