Endoplasmic reticulum–mitochondria contact sites are signalling hubs connecting nutrient sensing and GLP-1 secretion in L cells of the mouse gut: from physiology to obesity and type 2 diabetes
These results point to a new role for ER-mitochondria calcium coupling in glucose-induced GLP-1 secretion in L cells of the gut, which is impaired in obesity and type 2 diabetes, providing a novel target for the modulation of GLP-1 secretion. Therefore, these data reinforce the potential targeting of MAMs to improve glycaemic outcomes in metabolic diseases.
Authors
- Claudie Pinteur
- Aurélie Vieille‐Marchiset (ORCID: https://orcid.org/0000-0002-4382-8735)
- Nadia Bendridi (ORCID: https://orcid.org/0000-0003-0456-7007)
- Margaux Nawrot (ORCID: https://orcid.org/0000-0003-4442-7180)
- Bruno Guerci (ORCID: https://orcid.org/0000-0002-6211-464X)
- Yves Gouriou (ORCID: https://orcid.org/0000-0003-2565-4935)
- Alexandre Humbert (ORCID: https://orcid.org/0000-0001-9179-4341)
- Christine Durand
- Magalie A. Ravier (ORCID: https://orcid.org/0000-0001-6607-6559)
- Frank Reimann
- Marie‐Agnès Chauvin
- Nicolas Bertocchini
- Béatrice Morio
- Jingwei Ji-Cao
- Sophie Lestavel
- Jennifer Rieusset
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut de Cancérologie de Lorraine (FR)
- Hospices Civils de Lyon (FR)
- Centre de Recherche en Nutrition Humaine Rhône-Alpes (FR)
- Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition (FR)
- Addenbrooke's Hospital (GB)
- Université de Lorraine (FR)
Publication Details
- Journal
- Diabetologia
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1007/s00125-026-06693-7
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Université Claude Bernard Lyon 1
- European Association for the Study of Diabetes