Prediabetes and Type 2 Diabetes in Youth Following Premature Adrenarche

Compared with national estimates, we observed youth with PA demonstrated higher frequency of dysglycemia and obesity. While prior studies have shown increased insulin resistance in PA compared to all youth with obesity, this study is the first to demonstrate higher rates of subsequent youth-onset T2DM in this population. These findings support close longitudinal monitoring for dysglycemia in children with PA.