Next‐Generation Approach and Mechanistic Insight Mediated Beneficial Plant‐Microbe Interactions to Foster Resilient Agroecosystems and Sustain Soil Health

ABSTRACT Soil health is at risk from extreme weather, farming methods that harm the agroecosystem, and a loss of biodiversity. This makes it harder for ecosystems to recover and makes food security worse. Interactions between plants and microorganisms in the rhizosphere, particularly those involving nitrogen‐fixing bacteria, arbuscular mycorrhizal fungi (AMF), and plant growth‐promoting rhizobacteria (PGPR), are crucial for improving nutrient cycling, stress resistance, and soil structure. This review investigates the mechanistic and molecular underpinnings of these mutualistic connections, with a particular emphasis on the pivotal role of root exudates in regulating microbial recruitment and activity. Advancements in multi‐omics and ecological modeling have shown geographical and temporal dynamic patterns in root‐microbe interactions, providing novel insights into the formation of resilient and sustainable agroecosystems. The article examines innovative strategies, including synthetic microbial communities (SynComs), CRISPR‐based microbial engineering, host‐mediated microbiome selection, and precision inoculant delivery systems, as potential tools for restoring degraded lands, enhancing soil fertility, and developing climate‐resilient agricultural systems. These integrative techniques collaborate to create synthetic holobionts, which are plant‐microbiome capable of surviving in adverse environmental conditions. The impact of plant variety on microbial community composition is comprehensively examined, emphasizing functional redundancy and microbiome stability. This review presents a comprehensive framework for utilizing microbial breakthroughs to reduce reliance, restore soil health, enhance food security, and attain SDG‐2030 in the context of global climate change.