Endotoxemia and its association with immune and coagulopathy responses in severe community-acquired pneumonia and COVID-19

Using a highly specific LC-MS/MS method, we found no evidence of increased circulating LPS in severe pneumonia patients, challenging the hypothesis of gut-derived endotoxemia as a major contributor to systemic inflammation in severe CAP, including COVID-19. Take-home message Using a highly specific mass-spectrometry assay, we found no evidence of elevated circulating lipopolysaccharide in severe community-acquired pneumonia, including COVID-19. These findings challenge the concept that gut-derived endotoxemia is a major driver of systemic inflammation in severe pneumonia. Tweet Mass spectrometry reveals no rise in plasma LPS in severe pneumonia or COVID-19, questioning gut endotoxemia's role in inflammation.

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Publication Details

Journal
Intensive Care Medicine Experimental
Published
2026-03-09
DOI
https://doi.org/10.1186/s40635-026-00863-y
Primary Topic
Immune Response and Inflammation
Type
article
Field-Weighted Citation Impact
0.00

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article

Endotoxemia and its association with immune and coagulopathy responses in severe community-acquired pneumonia and COVID-19

Amadou-Khalilou Sow, Julie Marechal, Victoria Bergas, Karen Sagorny et al.
Intensive Care Medicine Experimental
Immune Response and Inflammation
article

Endotoxemia and its association with immune and coagulopathy responses in severe community-acquired pneumonia and COVID-19

Amadou-Khalilou Sow, Julie Marechal, Victoria Bergas, Karen Sagorny, I. Ben Ghezala, Florine Cattin, Alicia Taha, Hélène Choubley, Laure Stiel, Pascal Andreu, Mathieu Blot, David Masson, Pierre-Emmanuel Charles, Maxime Nguyen, Jérémy Barben, Bernard Bonnotte, Sylvie Nguyen, Jean-Paul Pais de Barros, Marie Labruyère, Hervé Devilliers, Philippe Bonniaud, Sébastien Prin, Thibaut Sixt, Maxime Luu, Julien Guy, Joao Pais-De-Barros, Jean-Baptiste Roudaut, Jean-Pierre Quenot, Marc Bardou, Marjolaine Georges, Marine Jacquier, Abderrahmane Bourredjem, Guillaume Beltramo, Jose Pineda, Christine Binquet, Thibault Sixt, Julie Ferrandes
article en

Abstract

Using a highly specific LC-MS/MS method, we found no evidence of increased circulating LPS in severe pneumonia patients, challenging the hypothesis of gut-derived endotoxemia as a major contributor to systemic inflammation in severe CAP, including COVID-19. Take-home message Using a highly specific mass-spectrometry assay, we found no evidence of elevated circulating lipopolysaccharide in severe community-acquired pneumonia, including COVID-19. These findings challenge the concept that gut-derived endotoxemia is a major driver of systemic inflammation in severe pneumonia. Tweet Mass spectrometry reveals no rise in plasma LPS in severe pneumonia or COVID-19, questioning gut endotoxemia's role in inflammation.

Intensive Care Medicine ExperimentalVol. 14(1)
Inserm (FR), Université de Bourgogne (FR), CHU Dijon Bourgogne (FR), Centre de recherche Translationnelle en Médecine moléculaire (FR)
Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale
Good health and well-being
Openalex Percentile: Top 29%
Immune Response and Inflammation
DOIOpen Access PDFOpenAlex
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