Calcium channel blockers affect angiogenesis by modulating inflammatory factors: a meta-analysis of randomized controlled trials

Angiogenesis is a process in which multiple factors work together to promote angiogenesis under the coordination of cytokines that promote angiogenesis and anti-angiogenic cytokines (original text: cytokines that resist angiogenesis). Neogenesis of blood vessels can occur in physiological conditions (such as wound healing, tissue cell regeneration, and female ovulation) and pathological conditions (such as tumor rheumatoid arthritis, etc.) (have deleted). The inflammatory factors IL-1, IL-6, TNF-α can participate in the regeneration of blood vessels through signal transduction pathways. Studies have shown that calcium channel blockers can synthesize proteins to regulate the stability of hypoxia-inducible factors, thereby affecting the production of blood vessels. The use of calcium channel blockers greatly reduces the secretion of inflammatory factors IL-1, IL-6, TNF-α; thereby, inhibiting angiogenesis.