A novel cannabidiol-derived small molecule ameliorates lower urinary tract dysfunction in mice with spinal cord injury via suppressing neuroinflammation
CIAC001 effectively ameliorates key symptoms of SCI-induced NLUTD in mice, primarily through suppressing neuroinflammation and facilitating neural repair. These findings highlight CIAC001 as a promising therapeutic candidate for neurogenic bladder dysfunction after SCI, warranting further mechanistic and translational investigation.
Authors
- Sha Jin
- Jinzhou Li
- Zhe Wang
- Wei Wang
- Xueyu Hu
- Jie Zhou
- Xiaohui Wang
- Xing Liu
- Yangguang Ma
- Tingyu Wu
- Lin Qiao
Institutions
- Hunan Institute of Science and Technology (CN)
- Jilin Academy of Traditional Chinese Medicine (CN)
- Baoji City Central Hospital (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1016/j.lfs.2026.124312
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00