Mitochondrial cristae density is increased following high-intensity interval training in men with type 2 diabetes

Skeletal muscle mitochondrial cristae density is not different between individuals with type 2 diabetes and glucose-tolerant individuals with obesity and lean individuals, and the capacity for cristae remodelling in response to exercise is not affected by type 2 diabetes. These findings highlight the plasticity of mitochondrial architecture and support HIIT as a potent stimulus for improving muscle oxidative and metabolic health in type 2 diabetes.