MicroRNA-625-3p Increases Chemosensitivity in Ovarian Cancer Cells Through Decreasing SSX2IP-Mediated Cisplatin Export in Extracellular Vesicles
These findings provide a new paradigm for intrinsic cisplatin resistance acquisition by HGSC cells, which will be crucial for developing new treatment strategies for ovarian cancer based on the upregulation of miR-625-3p or downregulation of SSX2IP to enhance cisplatin sensitivity and improve patient survival rates.
Authors
- Zahid H. Siddik (ORCID: https://orcid.org/0000-0002-6832-834X)
- Kay-Pong Yip
- J. Byeong
- Kwong-Kwok Wong
- Yadira Pacheco
- Guangan He
- Tetsushi Tsuruga
- Marina A. Talor
- Samuel C. Mok
- Chi-Lam Au-Yeung
- Suet-Ying Kwan
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of South Florida (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Cancers
- Published
- 2026-03-08
- DOI
- https://doi.org/10.3390/cancers18050872
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Texas MD Anderson Cancer Center