Blue Rubber Bleb Nevus Syndrome: Case-Driven Insights Into a Rare Cause of Refractory Gastrointestinal Bleeding

Blue rubber bleb nevus syndrome (BRBNS) is a rare vascular disorder causing chronic iron-deficiency anemia from gastrointestinal (GI) bleeding. We described the case of a 17-year-old Latin American patient with refractory anemia, cutaneous papules, and blue nevi. Endoscopic evaluations identified multiple bleeding lesions through the GI tract. Hot snare resection and clip placement achieved significant clinical improvement and stabilized hemoglobin levels. This case underscores the critical role of video capsule endoscopy and highlights the need for heightened awareness and diagnostic expertise in managing BRBNS.