Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities
This study presents the synthesis and comprehensive characterization of four novel metal-complexes formed from the reaction of copper(II), nickel(II), zinc(II), and vanadium(IV) salts with the bidentate ibuprofen Schiff base ligand (HL) in 1:1 metal-to-ligand ratio. The copper complex shows the highest antibacterial and cytotoxicity efficiency, in addition to a strong binding interactions with DNA. The in-vitro anti-inflammatory and anti-COVID-19 potencies of HL and its complexes were assessed, ranking them as: CuL > NiL > ZnL > VOL > HL.
Authors
- Mohamed R. Shehata (ORCID: https://orcid.org/0000-0003-1289-0285)
- Abdel-Mawgoud Abdel-Mawgoud
- Laila H. Abdel‐Rahman
- Doaa Abou El-ezz
- Mahmoud Abd El Aleem Ali Ali El-Remaily
- Mohamed Abdel-Hameed
- Shaaban K. Mohamed
Institutions
- Manchester Metropolitan University (GB)
- Cairo University (EG)
- October University of Modern Sciences and Arts (EG)
- Sohag University (EG)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1038/s41598-026-38270-8
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Development Fund