Exercise inhibits proliferation and induces apoptosis of lung adenocarcinoma cells via the POU2F2-SPOCD1-PI3K/AKT signaling axis
Exercise inhibits LUAD progression by downregulating the oncogenic transcription factor POU2F2. The POU2F2-SPOCD1 axis exerts its oncogenic function by activating the PI3K/AKT pathway. The POU2F2-SPOCD1 axis may represent a promising therapeutic target for LUAD.
Authors
- Haixin Tan
- Song Shi (ORCID: https://orcid.org/0000-0002-0757-8142)
- Linfei Yang
- Buyi Zhu
- Jiaqi Pan
- Wei Gu
- Zhenhua Yang
- Weiwei He
- Yumu Leng
- Fengming Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Sport Institute (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1007/s12094-026-04273-0
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00