Higher polygenic risk for cardiovascular disease is associated with lower cerebral blood flow in youth with bipolar disorder
Higher polygenic risk for cardiovascular disease was associated with lower regional CBF in youth with BD, convergent with prior findings in adults and divergent from healthy youth in the current study. Future longitudinal studies incorporating putative mediators of the observed findings are warranted.
Authors
- Megan Mio (ORCID: https://orcid.org/0000-0002-7411-7995)
- Bradley J. MacIntosh (ORCID: https://orcid.org/0000-0001-7300-2355)
- Clement Zai
- Nidhi P. Kulkarni
- Kody G. Kennedy
- Benjamin I. Goldstein
- L. Trevor Young
Institutions
- Sunnybrook Health Science Centre (CA)
- Centre for Addiction and Mental Health (CA)
- Heart and Stroke Foundation (CA)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1016/j.nbd.2026.107347
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00