Therapeutic effects of Tetramethylpyrazine on Cartilage in Rat Model of Post-traumatic Osteoarthritis
Intra-articular administration of TMP effectively restored joint function and ameliorated PTOA progression in model rats by promoting cartilage matrix repair, inhibiting inflammatory responses, and improving subchondral bone microstructure. These findings suggest TMP as a potential therapeutic agent for PTOA treatment.
Authors
- Hongpan Gao
- Z J Duan (ORCID: https://orcid.org/0009-0001-4994-6185)
- Benxiang He
- Si Tang
- Panpan Li
Institutions
- Chengdu Sport University (CN)
- Sichuan Integrative Medicine Hosipital (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1016/j.reth.2026.101098
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00