Deceased donor <scp>ABO</scp> discrepancy due to a rare <scp>AwB</scp> subgroup: Implications for organ allocation

This case highlights the vulnerability of routine serologic testing to misclassification of rare weak ABO subgroups. Integration of molecular genotyping with serologic testing can provide resolution of ABO discrepancies and enhance transplant safety. This case demonstrates a policy-relevant gap in current ABO determination workflows for deceased donors. Lack of standardized inter-laboratory data sharing and limited access to rapid molecular testing may unnecessarily restrict organ utilization.

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Publication Details

Journal
Transfusion
Published
2026-03-07
DOI
https://doi.org/10.1111/trf.70148
Primary Topic
Blood groups and transfusion
Type
article
Field-Weighted Citation Impact
0.00
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article

Deceased donor ABO discrepancy due to a rare AwB subgroup: Implications for organ allocation

Sara O. Dionne, Kelsey C. Smith, Brenden O'Neale, Luis Santiago
Transfusion
Blood groups and transfusion
article

Deceased donor ABO discrepancy due to a rare AwB subgroup: Implications for organ allocation

Sara O. Dionne, Kelsey C. Smith, Brenden O'Neale, Luis Santiago
article en

Abstract

This case highlights the vulnerability of routine serologic testing to misclassification of rare weak ABO subgroups. Integration of molecular genotyping with serologic testing can provide resolution of ABO discrepancies and enhance transplant safety. This case demonstrates a policy-relevant gap in current ABO determination workflows for deceased donors. Lack of standardized inter-laboratory data sharing and limited access to rapid molecular testing may unnecessarily restrict organ utilization.

Transfusion
Eurofins (Germany) (DE)
Openalex Percentile: Top 29%
Blood groups and transfusion
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