Association between the blaZ gene and the cefazolin inoculum effect among bloodstream isolates of methicillin-susceptible Staphylococcus aureus
The incidence of CzIE in MSSA was 12.4%. While blaZ type C was the most common, blaZ type A exhibited the most significant correlation with CzIE. Clinicians must remain alert for blaZ type A strains, as their significant inoculum effect may elevate the probability of cefazolin treatment failure in severe MSSA infections.
Authors
- Ye Xiao (ORCID: https://orcid.org/0000-0002-5876-4367)
- Yahong Qu
- Wenyan Zhu
- Huiqiong Jia
- Yaxi Gu
- Yuqing Chen
- Shengchao Li
- Qing Yang
Institutions
- Ningbo No. 2 Hospital (CN)
- Ningbo No.6 Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1016/j.jgar.2026.02.012
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00