Unveiling the association between low-density lipoprotein cholesterol lowering and fracture risk

In this population-based cohort study, LDL-C lowering was associated with a decreased risk of fracture in individuals with hyperlipidaemia. This decreased risk appeared to be associated with the extent of LDL-C lowering, suggesting that the therapeutic paradigm of 'lower is better' could be advantageous for fracture prevention in individuals with hyperlipidaemia.

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Publication Details

Journal
Bone and Joint Research
Published
2026-03-09
DOI
https://doi.org/10.1302/2046-3758.153.bjr-2025-0239.r1
Primary Topic
Bone health and osteoporosis research
Type
article
Field-Weighted Citation Impact
0.00

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article

Unveiling the association between low-density lipoprotein cholesterol lowering and fracture risk

Z. Wen, Houchen Lyu, Xiaoxiao Li, Chang Jun Li et al.
Bone and Joint Research
Bone health and osteoporosis research
article

Unveiling the association between low-density lipoprotein cholesterol lowering and fracture risk

Z. Wen, Houchen Lyu, Xiaoxiao Li, Chang Jun Li, Guanghua Lei, J H Wei, Yilun Wang, Junqing Xie, Yuqing Zhang, Chao Zeng
article en

Abstract

In this population-based cohort study, LDL-C lowering was associated with a decreased risk of fracture in individuals with hyperlipidaemia. This decreased risk appeared to be associated with the extent of LDL-C lowering, suggesting that the therapeutic paradigm of 'lower is better' could be advantageous for fracture prevention in individuals with hyperlipidaemia.

Bone and Joint ResearchVol. 15(3)
Harvard University (US), Central South University (CN), Hunan University (CN), Nuffield Orthopaedic Centre (GB), Chinese PLA General Hospital (CN), University of Oxford (GB), Massachusetts General Hospital (US), Xiangya Hospital Central South University (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 31%
Bone health and osteoporosis research
DOIOpen Access PDFOpenAlex
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Unveiling the association between low-density lipoprotein cholesterol lowering and fracture risk — Z. Wen, Houchen Lyu, et al. · Bone and Joint Research (2026) | TGRS Research Map | TGRS