Hormonal regulation of cochlear gene expression: effects of the estrous cycle, ovariectomy, and estradiol treatment
Both natural hormonal fluctuations across the proestrus and diestrus stages of the estrous cycle, as well as experimental hormone manipulation through ovariectomy and estradiol treatment, can modulate cochlear gene expression. These findings suggest that hormone-driven transcriptional changes may contribute to sex differences in auditory physiology and disease vulnerability.
Authors
- Mengxiao Ye (ORCID: https://orcid.org/0000-0002-4649-9244)
- Brandon Marzullo (ORCID: https://orcid.org/0000-0002-3547-1182)
- Celia Zhang (ORCID: https://orcid.org/0000-0003-4365-0874)
- Henry J. Adler
- Bo Hua Hu
Institutions
- University of the Pacific (US)
- The University of Texas at Dallas (US)
- University at Buffalo, State University of New York (US)
- University of North Texas at Dallas (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1186/s13293-026-00871-3
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00