The <scp>OX40</scp> / <scp>OX40L</scp> Axis Promotes Th2 Activity and Impairs Regulatory T Cell Function in Atopic Dermatitis
AD patients exhibit significant upregulation of OX40 expression in effector and regulatory CD4<sup>+</sup> T cells. Both subsets interact with OX40L-expressing cells in the skin, leading to the promotion of skin inflammation by downregulation of function and anti-inflammatory capacity of Tregs.
Authors
- E. Guttman‐Yassky
- K. Yamamura
- S. Garcet
- Madeline Kim (ORCID: https://orcid.org/0000-0002-8108-3631)
- Yeriel Estrada (ORCID: https://orcid.org/0000-0002-5172-6747)
- Hong Hur (ORCID: https://orcid.org/0000-0002-4088-9188)
- Mika Murai‐Yamamura (ORCID: https://orcid.org/0000-0002-0739-3551)
- Samuel C. Williams (ORCID: https://orcid.org/0000-0003-1916-1579)
- Juana Gonzalez (ORCID: https://orcid.org/0000-0001-7933-7017)
- S. Miura
- D. Dahabreh
- Jerry Zhou (ORCID: https://orcid.org/0000-0002-9741-0318)
- Xuan Li (ORCID: https://orcid.org/0000-0001-7021-8054)
- Ying Liu
- Daniel Lozano‐Ojalvo
- James G. Krueger
- Ester Del Duca
- Ragasruti Metukuru
Institutions
- Mount Sinai Medical Center (US)
- Rockefeller University (US)
- Sapienza University of Rome (IT)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Allergy
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1111/all.70252
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00