Oncolytic Adenoviral Infection of Chordoma Achieves Treatment Efficacy Associated with Immunologic Response and Tumor Microenvironmental Alteration
The immunosuppressive chordoma TME is associated with clinical outcomes and our data suggests OV infection reverses this deleterious immunosuppressive profile. These studies provide a framework for future clinical implementation amongst chordoma patients.
Authors
- D. Shin
- Juan Pardellas Fueyo
- Jen-Wei Tsai
- W.L. Wang
- Claudio E. Tatsui (ORCID: https://orcid.org/0000-0002-3615-0268)
- Andrew G. Gillard (ORCID: https://orcid.org/0000-0002-9704-7459)
- Anthony P. Conley (ORCID: https://orcid.org/0000-0002-6232-1163)
- Xizi Wu
- Daniel Ledbetter (ORCID: https://orcid.org/0000-0002-5877-5904)
- Robert Y. North
- A. Lazar
- KADİR AKDEMİR
- Shaan Raza
- Bo Zhao
- Joy Gumin
- Candelaria Gomez-Manzano
- Sanjay Singh
- Frederick F Lang
- Xuejun Fan
- Davis Ingram (ORCID: https://orcid.org/0000-0001-5967-1501)
- Christopher Alvarez-Breckenridge
- Hong Jiang
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2026-02-28
- DOI
- https://doi.org/10.1093/neuonc/noag045
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00