DENND2D serves as a novel prognostic biomarker with paradoxical protumorigenic effects in glioma
DENND2D acts as an oncogene in glioma, driving aggressiveness and shaping an immunosuppressive microenvironment. It represents a novel prognostic biomarker and therapeutic target for overcoming immunotherapy resistance.
Authors
- Feng Xiao (ORCID: https://orcid.org/0000-0002-7105-3092)
- Luyuan Zhang (ORCID: https://orcid.org/0000-0001-9972-0742)
- Hongxing Ye
- Yuxiang Weng
- Xiujue Zheng
- Renya Zhan
- Linghao Bu
- Weijian Fan
- Yu Zhu
- Hao Jiang
- Zhouying Peng
- Zebin Fang
- Chao Zhang
- Kaiyuan Huang
Institutions
- Central South University (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1007/s12672-026-04743-5
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00