Diagnosing and Treating Periodontitis and Multimorbidity Altogether: The Case Example of the Physical Exercise Hormone Irisin
Irisin is an extracellular peptide stimulated by exercise and could act as both a biomarker and mediate the positive impact of exercise. This scoping review synthesizes human evidence on irisin variations in non-communicable diseases, showing an increase of irisin in saliva and gingival tissues in periodontitis, potentially reflecting reparative or immunomodulatory activity.
Authors
- João Paulo Steffens (ORCID: https://orcid.org/0000-0002-6071-553X)
- Iain Chapple (ORCID: https://orcid.org/0000-0003-2697-7082)
- Søren Jepsen
- Larysa Saboya Cavalotti Perdonsini
- Rafael Scaf de Molon
Institutions
- Birmingham City University (GB)
- University of Bonn (DE)
- University College Birmingham (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- Universidade Federal do Paraná (BR)
- University of Birmingham (GB)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Journal of Periodontal Research
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1111/jre.70081
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00