N-Acetylcysteine Reduces Tissue Injury Induced by Oxygen–Glucose Deprivation in an Organotypic Culture of Mouse Cerebral Cortex Slices

This work highlights the direct effect of NAC in protecting cerebral cortex cells from OGD-induced damage and identifies the concentrations and time window that maximize the drug's effect. The results underscore the need for further studies to verify the in vivo efficacy of NAC at concentrations found to be active in vitro, and for clinical trials to evaluate whether NAC can reduce hypoxia-induced brain damage in newborns.